بررسی سطح سرمی C–Reactive Protein Mannoseو Mannose–Binding Lectin در افراد مبتلا به درماتوفیتوزیس

Background: Interleukin8 (IL-8) realized from keratinocytes in the presence of dermatophytic antigens causesinduction of acute responses in dermatophyte infection and subsequently production of acute phaseproteins occurs in hepatocytes. C–reactive protein (CRP) and Mannose–binding lectin (MBL) areacute phase proteins. Since few researches in the case of acute phase proteins in dermatophyticinfections has been accomplished, this study has been designed for determining serum CRP and MBLlevels in patients affected to dermatophytosis.Dermatophytosis is common cutaneous fungal disease with worldwide distribution.Methods: and 105 patients affected to dermatophytosis with non probable and in access procedure. For isolationand identification of dermatophyte direct microscopic examination, culturing and complementaryexaminations were done and for determination of serum CRP and MBL levels in healthy individualsand in patients ELISA test were used. For investigation of relevance between variables, Chi-square,Fisher exact, Mann-Whitney and Roc curve analysis were used and p< 0.05 was considered asmeaningful level.This was a cross sectional study and samples were carried out on 96 healthy individualsResults: 3.31±3.32μg/ml and 16.60±35.96 μg/ml (p<0.001) respectively and the median serum MBL level was1.53±1.87 μg/ml and 1.97±2.03μg/ml (p=0.039) respectively. CRP (p<0.001) and MBL (p=0.042)were determined meaningful parameters for dermatophytosis. MBL deficiency (MBL concentrations<1 μg/ml) was higher in control subjects (56.2%) than in patients (41.0%).The median serum CRP level in healthy individuals and in patients group wasConclusion: affected to dermatophytosis and their role in this infection. Probably observation of high frequency ofMBL deficiency in healthy individuals in compare with patients group indicates that it is notpredisposing factor in affecting to dermatophytosis.Findings of this study indicate increased concentrations of CRP and MBL in patients